TAURINE FOR HEART DISEASES!

TAURINE FOR HEART DISEASES!

1. Taurine (2-aminoethane- sulfonic acid) is the most abundant free amino acid there is in our body [1]. It has various functions throughout the body such as regulation of cell volume, serving as substrate for the formation of bile salts and regulation of the concentration of extracellular free calcium and many cytoprotection effects (protection to the cells). 
2. It’s deficiency is associated to cardiomyopathy, damages to the retinal neurons, renal dysfunction and developmental abnormalities. Hence, taurine is one of the most essential substances of the body [2]. 
3. It can be found in food mostly in fish and shell fish and represents about 60% of the amino acids present in mammalian heart. The heart can make it’s own taurine, but the major myocardial uptake is from the plasma [3]. And although the taurine can be produced by the body, the main source of it is the food [4]. 
4. Many benefits of taurine are due to it’s antioxidant ability (free radical scavening) [5]. The main role of taurine is to give cytoprotection and to keep the homeostasis in cells involved in inflamatory/oxidative stress [6]. 
5. Taurine has a lot of roles in the heart, been therefore a very important substance to this organ. For exemple, taurine increases contractility, prevents reduction in cardiac function, and it has protection effects against cardiac injury caused by calcium overload [7]. 
6. Many clinical studies showed that taurine does help the cardiovascular system via several mechanisms, such as improving lipid profile, modulation of calcium (Ca²+), antioxidant action and antagonism of Ang II action (Ang II is a hormone that causes vasoconstriction). Also, Ang II causes the production of reactive oxygen species (ROS). The antagonist action of Ang II caused by taurine might be due to it’s antioxidant action.  On the other hand, modulation of calcium (Ca²+) might help the heart because congestive heart failure (CHF) causes inadequacy in calcium homeostasis [8].
7. It was found a significant improve in some parameters in patients with congestige heart failure treated with taurine, such as left ventricle function, with an increase in ejection fraction, cardiac output and stroke volume [9]. Also, it was found an improvement in dyspnea and palpitation in patents with congestige heart failure [10]. Taurine also has anti-artherogenic and also anti-inflamatory efects in patients with heart failure [11]. Not only that, but taurine also has anti-trombotic effect [12]. Taurine also might have a protective effect in the heart during ischeamia, reducing myocardial injury [13].
8. Taurine also might improve myocardial oxygen consumption and electrical activity of the heart [14].
9. It was used 3 g per day of taurine during 6 weeks period for patients with congestive heart failure and left ventricule dysfunction. The result was 70% of improvement, with a significant improve in systolic left ventricule function [15]. 
10. Although no adverse effects have been reported from the use of taurine, the use of energy drinks that also contain caffeine might be used with caution [16].
11. Also, the supplementation with taurine increases exercise performance [17].
12. Check out more information about others supplements that can help in cardiovascular diseases such as  turmeric,  vitamin d3 and CoQ10. 

Disclaimer: This article is not meant to give any medical advice, diagnosis or treatment. Views existed here do not necessarily match those of Biohacking your Heart! or it's staff. The information presented on this article does not intend to surrogate a consult with your health care professional and does not have the intention of giving any medical suggestion. Do not use the information obtained on this website to diagnose, treat, or prescribe any medications or supplements. The information regarding supplementation have not been evaluated by the US Food and Drug Administration and does not have the intention of diagnose, treat or prevent any disease. By using this website you accept all the terms in the disclaimer in full extent. If you don’t agree with any of this disclaimer do not use https://biohackingyourheart.blogspot.com/. We have the right to change this terms any time we judge it's necessary. Therefore you should check out for updates periodically. All information is based on science research and on the life experiencing of the author and by no means should be used as an example to be copy out. You should always consult your health care professional before do anything regarding your health.
    Copyright © 2017 Biohacking your Heart. All Rights Reserved.
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     REFERENCES

    [1] Ahmadian M, Roshan VD, Aslani E and Stannard SR. (2017). Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure. Ther Adv Cardiovasc Dis. 11(7):185-194.
    [2] Ripps H and Shen W. (2012). Review: taurine: a "very essential" amino acid. Mol Vis. 18:2673-86.
    [3] Azuma J, Sawamura A and Awata N. (1992). Usefulness of taurine in chronic congestive heart failure and its prospective application. Jpn Circ J. 56(1):95-9.
    [4] Xu Y-J, Arneja AS, Tappia PS, Dhalla NS. (2008). The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol. 13(2):57-65.
    [5] Ahmadian M, Roshan VD, Aslani E and Stannard SR op cit.
    [6] Marcinkiewicz J and Kontny E. (2014). Taurine and inflammatory diseases. Amino Acids. 46(1):7-20.
    [7] Azuma J, Sawamura A and Awata N. op cit.
    [8] Xu Y-J, Arneja AS, Tappia PS, Dhalla NS op cit.
    [9] Azuma J, Sawamura A and Awata N. op cit.
    [10] Azuma, J, Sawamura, A and Awata, N. (1983). Double-blind randomized crossover trial of taurine in congestive heart failure. Current Therapeutic Research - Clinical and Experimental 34:543-557.
    [11] Ahmadian M, Roshan VD, Aslani E and Stannard SR op cit.
    [12] Ijiri Y, Ikarugi H, Tamura Y et al.  (2013). Antithrombotic effect of taurine in healthy Japanese people may be related to an increased endogenous thrombolytic activity. Thromb Res. 131(2):158-61.
    [13] Miyamoto TA, Ueno T, Iguro Y et al. (2009). Taurine-mediated cardioprotection is greater when administered upon reperfusion than prior to ischemia. Adv Exp Med Biol. 643:27-36.
    [14] Ahmadian M, Roshan VD and Ashourpore E. (2017): Taurine Supplementation Improves Functional Capacity, Myocardial Oxygen Consumption, and Electrical Activity in Heart Failure. Journal of Dietary Supplements 14(4):422-432.
    [15] Azuma J, Sawamura A, Awata N. (1992). Usefulness of taurine in chronic congestive heart failure and its prospective application. Jpn Circ J. 56(1):95-9.
    [16] Rath M. (2012). Energy drinks: what is all the hype? The dangers of energy drink consumption. J Am Acad Nurse Pract. 24(2):70-6.
    [17] Ahmadian M, Roshan VD, Aslani E and Stannard SR op cit. 

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    Copyright © 2017 Biohacking your heart. All Rights Reserved. December 1, 2017.

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