CoQ10 - Coenzyme Q10 for a strong heart!

  CoQ10 - Coenzyme Q10 for a strong heart!

1. A simple search on the oracle google with the words Coenzyme Q10 gives an outstanding  3.480.000 results. But if you ask google scholar, then the result is 50.500 results of scientific articles available for study. Hence, there's a lot of science available about this supplement; 
2. It’s also known as Coenzyme Q10, ubiquinone, ubiquinol and ubidecarenone and it was discovered in 1957; 
3. Although it can be produced by the body it requires at least eight vitamins and many trace elements and is a multistage process [1]. Therefore, it's not easy to the body to produce it; 
4. Science is positively conclusive about the use of CoQ10 for all sorts of cardiovascular diseases. Most of the benefits of CoQ10 came from it’s role in improving the capability of the cells to produce energy [2];
5. CoQ10 is found in the “batteries” of the cells – the mitochondria, which are the organelles responsible to burn food, converting it in energy via APT molecules;
6. Remember, the heart never stops pumping, so it needs constant and efficient production of energy in it’s cells, especially in the cells of the muscle heart (cardiomyocytes). Imagine that you would need to keep doing an exercise to you biceps, to keep moving your arm to exercise your biceps without stopping it anymore. After a while doing this you would feel done! So now you can imagine how strong and resilient is the the myocardium muscle, and how much energy it requires to keep exercising forever. It's the only muscle in our bodies that starts exercising when you are still at your mother's belly and only stops the day you die; 
7. CoQ10 is a very important molecule that exists on the heart muscle in great abundance, (but also in every cell of the body in the mitochondria) and has an important role of giving energy (it helps to produce ATP – the molecule of energy) and, therefore, to help the heart to keep pumping efficiently;
8. It’s been prove that a supplementation intake of CoQ10 does increase the levels of CoQ10 in the heart tissues and in the mitochondria of the heart too, and also improves mitochondrial efficiency and even improves the resistance of myocardium cells to hypoxia-reoxigenation [3];
9. Clearly you need the righ quantity of CoQ10 inside the mitochondria of the heart muscle (cardiomyocytes) in order to improve the strength of your heart, especially after a Heart Attack or any surgeries in the heart;
10. Also many cardiovascular diseases have been correlated to low levels of CoQ10 [4]. Such as 70 – 75% of cases of heart disease occur the patients that have low levels of CoQ10 [5];
11. CoQ10 also has effect for treatment of hypertension as many studies have shown the efficacy of CoQ10 to reduce blood pressure in hypertension patients [6]; 
12. CoQ10 is also an anti-arrhythmic agent [7], and it’s mechanism of action might be related to the power of CoQ10 in reduce ischemia that can cause arrhythmia and also by it’s power to enhance the energy production in the heart muscle cells [8];
13. Also it’s important to mention that CoQ10 has an antioxidant effect, been a free radical scavenger [9];
14. Statins medication (medications to low the cholesterol levels) causes decrease of the CoQ10 level [10]; 
15. The dosages suggested to keep normal levels of CoQ10 in the serum vary in between 30-60 mg/day. But in order to have clinical benefits the dosage must be in between 60-120 mg/day and 120-180 mg/day [11];
16. However, to treat chronic heart disease the optimum dosage is 100-200 mg/day [12];
17. It is suggested that several mounts with high dosage might be necessary in order to get the concentration levels of CoQ10 high in the body (especially in the heart) and also to give time to the body to fabricate dependent apoenzimes that are necessary to work together with CoQ10 [13];
18. But more recently it was found that, in order to improve the fraction ejection (which is basically the fraction of blood that the heart can pump each time) it’s necessary higher dosages such as 450 mg/day. This dosage was capable to improve the fraction ejection from 24% to 45% [14]. This basically represents a great recovery of the heart capability to pump blood each time;
19. That also indicates a consequent improve in cardiovascular capability, resulting in improve in exercises and less fatigue; 
20. The risk of high dosages intake of CoQ10 was tested in 2006  and the researchers conclude that up to 1.200 mg/day is safe to take [15].
21. Don't forget to check out more information about how turmeric can help in cardiovascular diseases and also how the sun and vitamin d3 are very important in combating cardiovascular diseases.

Disclaimer: This article is not meant to give any medical advice, diagnosis or treatment. Views existed here do not necessarily match those of Biohacking your Heart! or it's staff. The information presented on this article does not intend to surrogate a consult with your health care professional and does not have the intention of giving any medical suggestion. Do not use the information obtained on this website to diagnose, treat, or prescribe any medications or supplements. The information regarding supplementation have not been evaluated by the US Food and Drug Administration and does not have the intention of diagnose, treat or prevent any disease. By using this website you accept all the terms in the disclaimer in full extent. If you don’t agree with any of this disclaimer do not use https://biohackingyourheart.blogspot.com/. We have the right to change this terms any time we judge it's necessary. Therefore you should check out for updates periodically. All information is based on science research and on the life experiencing of the author and by no means should be used as an example to be copy out. You should always consult your health care professional before do anything regarding your health.

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REFERENCES

[1] Singh R B et al. Coenzyme Q10 and Its Role in Heart Disease. J. Clin. Biochem. Nutr. 26, 1999; 109-118.

[2] Kumar, A, Kaur, H, Devi, P and Mohan, V. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther. 2009 Dec;124(3):259-68. Epub 2009 Jul 25.

[3] Rosenfeldt F, et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. 

[4] Garrido-Maraver, J. , Cordero, MD, Oropesa-Ávila, M, Veja, AF, de la Mata, M, Pavón, AD, de Miguel, M, Calero,CP, Paz, MV, Cotán, D and Sánchez-Alcázar, JA. Coenzyme Q10 Therapy. Mol Syndromol. 2014 Jul; 5(3-4): 187–197.

[5] Folkers, K, Littarru, G P, Ho, L, Runge, T M, Havanonda, S, & Cooley, D (1970). Evidence for a deficiency of coenzyme Q10 in human heart disease. Int J Vitam Nutr Res 40, 380–390.

[6] Kumar et alli, op. cit., p. 264.

[7] Fujioka T, Sakamoto, S, Mimura, G. Clinical Study of Cardiac Arrhythmias Using a 24-Hour Continuous Electrocardiographic Recorder (5 th Report) - Antiarrhythmic Action of Coenzyme Q 10 in Diabetics -. Med., 1983, 141, Suppl., 453-463.

[8] Kumar et alli, op. cit., p. 264.
[9] Kumar et alli, op. cit., p. 260-261.

[10] Ghirlanda, G, Oradei, A, Manto, A, Lippa, S, Uccioli, L, Caputo, S, Greco, AV., Littarru, GP (1993). Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J Clin Pharmacol.

[11] Kumar et alli, op. cit., p. 260.

[12] Kumar et alli, op. cit., p. 260.
[13] Kumar et alli, op. cit., p. 260.
[14] Langsjoen P. 5th Annual International CoQ10 Symposium. Kobe, Japan: November 9-12, 2007.

[15] Hathcock, J. N, & Shao, A (2006). Risk assessment for coenzyme Q10 (ubiquinone). Regul Toxicol Pharmacol 45, 282–288.
Adabag, ASJ, Therneau, TM, Gersh, BJ, Weston, SA, Roger, VL. Sudden Death after Myocardial Infarction. JAMA. 2008 Nov 5; 300(17): 2022–2029.

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Copyright © 2017 Biohacking your heart. All Rights Reserved. November 23, 2017.